Anti-CTLA-4 and anti-PD-1 immunotherapies repress tumor progression in preclinical breast and colon model with independent regulatory T cells response

The Coaxial Tools recent development of immunotherapy represents a significant breakthrough in cancer therapy.Several immunotherapies provide robust efficacy gains in a wide variety of cancers.However, in some patients the immune checkpoint blockade remains ineffective due to poor therapeutic response and tumor relapse.An improved understanding of

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Molecular characterization of the partial coat protein gene of an Onion yellow dwarf virus isolate detected in garlic (Allium sativum L.) from the West Shewa zone of Ethiopia

Onion yellow dwarf virus (OYDV), an aphid-borne potyvirus is one of the major viral pathogens of garlic causing significant yield losses worldwide.It is found almost everywhere in the Parts world where Allium species is grown.The aim of this study was to test the presence of OYDV infection in garlic from Ethiopia.The presence of the virus was teste

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Characterisation of Shigella species isolated from river catchments in the North West province of South Africa

The occurrence and distribution of Shigella species in water from the five river catchments in the North West province of South Africa were investigated.Shigella is a Gram-negative, non-motile, facultative anaerobic bacillus that causes shigellosis, an important cause of morbidity and mortality in high-risk populations (such as children, the elderl

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